Features of matrix metalloproteinases MMP2, MMP3, MMP9 genes regulatory region polymorphism in patients with uterine fbroids

Violation of the extracellular matrix components synthesis regulation contributes to formation and growth uterine fbroids (MM). Changes collagen metabolism in connective tissue may be associated with polymorphism metalloproteinase (MMP) genes. Aim study was analyze association regulatory regions genes MMP2 (rs243865), MMP3 (rs3025058), MMP9 (rs3918242) development myoma, its histological form, several concomitant gynecological diseases. Material methods. The clinical 69 patients (23–54 years old) myoma conducted. According anamnesis, 57.9 % had childbirth, 46.4 women an artifcial termination pregnancy, 15.9 endometriosis. In examination, 48.14 nodes corresponded phenotype simple a large proportion fbrous tissue, 51.6 proliferating fbroids. comparison group is represented by random population sample from Western Siberia. 183 without pronounced pathologies were examined. MMP2-1306 C/T analyzed TaqMan, MMP3-1171 5A/6A, MMP9-1562 restriction fragment length method. Results. genotype frequencies did not signifcantly differ between groups. complex MMP2-1306CC:MMP3-11715A6A:MMP9-1562CT decreased relative persons group. endometriosis MMP9-1562CC reduced heterozygosity increased frequency MMP2-1306CC:MMP9-1562CT higher who gave birth than give birth. Complex genotypes differences variants revealed. Conclusions. results show signifcance effect MMP nature course myoma.